TF 0315M ALC-0315 Structural Characterization Using ZenoTOF 7600 System

Product Description

The TF 0315M application note discusses the structural characterization of [(4-hydroxybutyl)azanediyl]di(hexane-6,1-diyl) bis(2-hexyldecanoate), known as ALC-0315, and its impurities. The analysis uses EAD fragmentation on the ZenoTOF 7600 system to detect impurities present at relative abundances as low as 0.19%. EAD generates diagnostic fragments that aid in the structural elucidation of singly charged compounds, particularly when collision-induced dissociation is insufficient.

• EAD fragmentation on the ZenoTOF 7600 system allows for effective structural characterization of ALC-0315.
• MS/MS spectra assist in elucidating low-abundance impurities, which include oxidation and hydroxyl-to-carboxyl transformations.
• Lipid impurities are detected and reported at levels lower than 0.2% relative to the main peak using the Zeno trap.

Product Highlights

This application note emphasizes the capability of the ZenoTOF 7600 system in detailing the composition and related impurities of ALC-0315.

Product Information

Standard Information

• Brand: TF
• MPN: 0315M

Technical Specifications

• Detection Limit: 0.19% relative abundance
• Application: Structural characterization of ALC-0315
• System Used: ZenoTOF 7600
• Method: EAD fragmentation